Over time, indigenous cultures in North America grew increasingly complex, and some, such as the pre-Columbian Mississippian culture in the southeast, developed advanced agriculture, grand architecture, and state-level societies. The Mississippian culture flourished in the south from 800 to 1600 AD, extending from the Mexican border down through Florida. Its city state Cahokia is considered the largest, most complex pre-Columbian archaeological site in the modern-day United States. In the Four Corners region, Ancestral Puebloans culture developed as the culmination of centuries of agricultural experimentation, which produced greater dependence on farming. Three UNESCO World Heritage Sites in the United States are credited to the Pueblos: Mesa Verde National Park, Chaco Culture National Historical Park, and Taos Pueblo. The earthworks constructed by Native Americans of the Poverty Point culture in northeastern Louisiana have also been designated a UNESCO World Heritage site. In the southern Great Lakes region, the Iroquois Confederacy (Haudenosaunee) was established at some point between the twelfth and fifteenth centuries.