In the past 20 years dos Santos has held management positions in a number of companies listed on European stock exchanges. Dos Santos returned from London in the early 1990s to join her father in Luanda and started working as a project manager engineer for Urbana 2000, a subsidiary of Jembas Group, that had won a contract to clean and disinfect the city. Following that, she set up a trucking business. The widespread use of walkie-talkie technology paved the way for her subsequent foray into telecoms. In 1997, she started her first business, opening the Miami Beach Club, one of the first night clubs and beach restaurants on the Luanda Island. Over nearly 20 years she expanded her business interests, leading to the creation of several holdings, in Angola and mostly abroad, making substantial investments in high-profile entreprises, especially in Portugal. In June 2016, she was appointed by her father as chairwoman of Sonangol, the Angolan state oil company. The controversial appointment in the wake of similar appointments of children of the president to key posts was short-lived, as João Lourenço, the new Angolan President, fired her merely two months after being sworn into office.